One of the key areas in pharmaceuticals is the precise targeting of Drugs to selected cells or tissues. Drug targeting systems must control the fate of the Drug entering the body. Today's delivery technologies are numerous, with the so-called "magic bullet" scheme proposed by Paul Ehrlich at the beginning of the 20th century, in which the Drug is delivered precisely to the target. Nano Drug delivery systems (NDDSs) are categories of nanomaterials that increase the stability and solubility of Drugs in water, prolong the cycle time, increase the absorption rate of target cells or tissues, and reduce enzymes, thus improving safety. And Drug efficacy NDDS can be administered through existing routes including inhalation, oral administration or intravenous injection and remains better bioavailability. Nanoparticles are classified as nanoparticles with a diameter between 10 and 100 nm. During the design of nanoparticles, some controls such as release patterns and surface properties should be taken into account, which, with an appropriate dosing scheme, determine the activation of specific sites at optimal rates. Many new carriers have been registered for implants in the last ten years, including nanosomes, nanophytosomes, nanoemulsions, transferosomes, and autosomes. The aim of this study is to synthesize various newly developed technologies for Drug delivery of herbal medicines to improve therapeutic response.

Nanoparticles have been developed as an important strategy to deliver conventional Drug, recombinant protein, vaccines, and other biomolecules. Nanopatticles are tiny material (<1000nm in size) that have specific physiochemical properties different to bulk material of the same composition and such properties make them very attractive for commercial and medical development. Application of nanoparticles and nanomaterials for the diagnostic and therapeutic purpose is now significantly extended in nanomedicine. Use of Nanobiotechnology approach and nanomaterials open new prospects for creation of Drug and system for their directed transport. delivery of these molecules to specific areas with the body can be achieved, which will reduces systemic side effects and allow for more efficient use of the Drug. Polymeric nanoparticles have demonstrated enormous potential as cellular Drug delivery vehicles. The potential of Drug delivery system based on the use of nanoparticles from significant advantage such as: (i) the ability of target specific location in the body; (ii) the reduction of the quantity of Drug needed to attain a particular concentration in the vicinity of the target; and (iii) the reduction of the concentration of the Drug at nanotarget size minimizing severe side effect, and also cellular Drug delivery using nanoparticles is also affected by clearance through the reticuloendothelial system. Nanoparticles including dendrimers (3-5nm), micelle (5-10nm), emulsion (100-150nm), nano particulates system (20-150nm) and liposome (100-150nm) are used to target specific area in the body. The nanoprticles must be endow with characteristic needed to reach a given target, which means attaining a suitable combination of nature, size, way of conjugating the Drug to the NP (attach, absorbed, encapsulated), surface chemistry, hydrophilicity/hydrophbicity, surface functionalization, biodegradability, and physical response properties (temperature, PH, electric charge, light, sound, magnetism).